Adobe Digital Editions (ADE) 3.0 and above versions are designed to work with accessibility / assistive technologies on Mac and Windows.
ADE Version 3.0 and above are designed with support for full keyboard controls (tab navigation and shortcuts), improved text enlargement, and support for high-contrast modes. Shortcuts are listed in the Getting Started eBook that is installed along with the Adobe Digital Editions.
For mobile devices, iOS has a screen reader called VoiceOver and Android has one called TalkBack.
Our Online Reader also has a "read aloud" function. For more information please see our article on using read aloud functionality.